Histological biocompatibility of new, non-absorbable glaucoma deep sclerectomy implant.
Identifieur interne : 000230 ( Main/Exploration ); précédent : 000229; suivant : 000231Histological biocompatibility of new, non-absorbable glaucoma deep sclerectomy implant.
Auteurs : Jakub J. Kałuzny [Pologne] ; Wojciech J Wicki ; Halina Wi NiewskaSource :
- Journal of biomedical materials research. Part B, Applied biomaterials [ 1552-4973 ] ; 2007.
Descripteurs français
- KwdFr :
- Acide hyaluronique (effets indésirables), Animaux (MeSH), Glaucome (chirurgie), Hydrogels (MeSH), Implants de drainage du glaucome (effets indésirables), Lapins (MeSH), Matériaux biocompatibles (effets indésirables), Poly(acides méthacryliques) (effets indésirables), Réactifs réticulants (MeSH), Sclère (anatomopathologie), Sclère (chirurgie), Sclérostomie (effets indésirables), Sclérostomie (méthodes), Siloxane élastomère (effets indésirables), Test de matériaux (MeSH).
- MESH :
- anatomopathologie : Sclère.
- chirurgie : Glaucome, Sclère.
- effets indésirables : Acide hyaluronique, Implants de drainage du glaucome, Matériaux biocompatibles, Poly(acides méthacryliques), Sclérostomie, Siloxane élastomère.
- méthodes : Sclérostomie.
- Animaux, Hydrogels, Lapins, Réactifs réticulants, Test de matériaux.
English descriptors
- KwdEn :
- Animals (MeSH), Biocompatible Materials (adverse effects), Cross-Linking Reagents (MeSH), Glaucoma (surgery), Glaucoma Drainage Implants (adverse effects), Hyaluronic Acid (adverse effects), Hydrogels (MeSH), Materials Testing (MeSH), Polymethacrylic Acids (adverse effects), Rabbits (MeSH), Sclera (pathology), Sclera (surgery), Sclerostomy (adverse effects), Sclerostomy (methods), Silicone Elastomers (adverse effects).
- MESH :
- chemical , adverse effects : Biocompatible Materials, Hyaluronic Acid, Polymethacrylic Acids, Silicone Elastomers.
- adverse effects : Glaucoma Drainage Implants, Sclerostomy.
- methods : Sclerostomy.
- pathology : Sclera.
- surgery : Glaucoma, Sclera.
- Animals, Cross-Linking Reagents, Hydrogels, Materials Testing, Rabbits.
Abstract
We performed this study to compare the intrascleral biocompatibility of three materials: non-absorbable hydrogel contact lens polymer, non-absorbable silicone rubber, and absorbable cross-linked sodium hyaluronate. Intrascleral implantation of three different materials was performed in 13 healthy, pigmented rabbits. Implants of methacrylic hydrogel, silicone rubber, and cross-linked sodium hyaluronate were implanted in 10, 8, and 8 eyes, respectively. The animals were euthanized at 7, 30, 180, and 360 days post implantation. The eyes were enucleated and immediately fixed in 10% buffered formalin. Semithin sections were cut and stained with hematoxylin-eosin. Light microscope analysis of the specimens was performed. The least severe inflammatory reaction was observed with cross-linked sodium hyaluronate implants. The number of inflammatory cells in proximity to methacrylic hydrogel and silicone implants at all periods of follow up was similar. The thickest fibrous capsule was observed with silicone implants (average, 28.38 +/- 11.17 microm). This area was thinner with methacrylic hydrogel implants (average, 14.90 +/- 5.57 microm) and was thinnest around sodium hyaluronate implants (average, 7.21 +/- 2.33 microm). For each type of implant, the wall on the conjunctival side of the fibrous capsule was significantly thicker than the wall on the choiroidal side. The space between the implant, scleral flap, and bed was filled soon after surgery with connective tissue rich in vessels. In our study, cross-linked sodium hyaluronate had the highest intrascleral biocompatibility. Although the inflammatory responses of the sclera to methacrylic hydrogel and silicone rubber were similar in nature, a thicker fibrous capsule was generated around silicone implants.
DOI: 10.1002/jbm.b.30677
PubMed: 17022058
Affiliations:
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Kałuzny</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland. kubeye@poczta.onet.pl</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Ophthalmology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz</wicri:regionArea><wicri:noRegion>Bydgoszcz</wicri:noRegion></affiliation></author><author><name sortKey="J Wicki, Wojciech" sort="J Wicki, Wojciech" uniqKey="J Wicki W" first="Wojciech" last="J Wicki">Wojciech J Wicki</name></author><author><name sortKey="Wi Niewska, Halina" sort="Wi Niewska, Halina" uniqKey="Wi Niewska H" first="Halina" last="Wi Niewska">Halina Wi Niewska</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17022058</idno><idno type="pmid">17022058</idno><idno type="doi">10.1002/jbm.b.30677</idno><idno type="wicri:Area/Main/Corpus">000242</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000242</idno><idno type="wicri:Area/Main/Curation">000239</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000239</idno><idno type="wicri:Area/Main/Exploration">000239</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Histological biocompatibility of new, non-absorbable glaucoma deep sclerectomy implant.</title><author><name sortKey="Kaluzny, Jakub J" sort="Kaluzny, Jakub J" uniqKey="Kaluzny J" first="Jakub J" last="Kałuzny">Jakub J. Kałuzny</name><affiliation wicri:level="1"><nlm:affiliation>Department of Ophthalmology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland. kubeye@poczta.onet.pl</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Ophthalmology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz</wicri:regionArea><wicri:noRegion>Bydgoszcz</wicri:noRegion></affiliation></author><author><name sortKey="J Wicki, Wojciech" sort="J Wicki, Wojciech" uniqKey="J Wicki W" first="Wojciech" last="J Wicki">Wojciech J Wicki</name></author><author><name sortKey="Wi Niewska, Halina" sort="Wi Niewska, Halina" uniqKey="Wi Niewska H" first="Halina" last="Wi Niewska">Halina Wi Niewska</name></author></analytic><series><title level="j">Journal of biomedical materials research. Part B, Applied biomaterials</title><idno type="ISSN">1552-4973</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Biocompatible Materials (adverse effects)</term><term>Cross-Linking Reagents (MeSH)</term><term>Glaucoma (surgery)</term><term>Glaucoma Drainage Implants (adverse effects)</term><term>Hyaluronic Acid (adverse effects)</term><term>Hydrogels (MeSH)</term><term>Materials Testing (MeSH)</term><term>Polymethacrylic Acids (adverse effects)</term><term>Rabbits (MeSH)</term><term>Sclera (pathology)</term><term>Sclera (surgery)</term><term>Sclerostomy (adverse effects)</term><term>Sclerostomy (methods)</term><term>Silicone Elastomers (adverse effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide hyaluronique (effets indésirables)</term><term>Animaux (MeSH)</term><term>Glaucome (chirurgie)</term><term>Hydrogels (MeSH)</term><term>Implants de drainage du glaucome (effets indésirables)</term><term>Lapins (MeSH)</term><term>Matériaux biocompatibles (effets indésirables)</term><term>Poly(acides méthacryliques) (effets indésirables)</term><term>Réactifs réticulants (MeSH)</term><term>Sclère (anatomopathologie)</term><term>Sclère (chirurgie)</term><term>Sclérostomie (effets indésirables)</term><term>Sclérostomie (méthodes)</term><term>Siloxane élastomère (effets indésirables)</term><term>Test de matériaux (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Biocompatible Materials</term><term>Hyaluronic Acid</term><term>Polymethacrylic Acids</term><term>Silicone Elastomers</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Glaucoma Drainage Implants</term><term>Sclerostomy</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Sclère</term></keywords><keywords scheme="MESH" qualifier="chirurgie" xml:lang="fr"><term>Glaucome</term><term>Sclère</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Acide hyaluronique</term><term>Implants de drainage du glaucome</term><term>Matériaux biocompatibles</term><term>Poly(acides méthacryliques)</term><term>Sclérostomie</term><term>Siloxane élastomère</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Sclerostomy</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Sclérostomie</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Sclera</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Glaucoma</term><term>Sclera</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cross-Linking Reagents</term><term>Hydrogels</term><term>Materials Testing</term><term>Rabbits</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Hydrogels</term><term>Lapins</term><term>Réactifs réticulants</term><term>Test de matériaux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We performed this study to compare the intrascleral biocompatibility of three materials: non-absorbable hydrogel contact lens polymer, non-absorbable silicone rubber, and absorbable cross-linked sodium hyaluronate. Intrascleral implantation of three different materials was performed in 13 healthy, pigmented rabbits. Implants of methacrylic hydrogel, silicone rubber, and cross-linked sodium hyaluronate were implanted in 10, 8, and 8 eyes, respectively. The animals were euthanized at 7, 30, 180, and 360 days post implantation. The eyes were enucleated and immediately fixed in 10% buffered formalin. Semithin sections were cut and stained with hematoxylin-eosin. Light microscope analysis of the specimens was performed. The least severe inflammatory reaction was observed with cross-linked sodium hyaluronate implants. The number of inflammatory cells in proximity to methacrylic hydrogel and silicone implants at all periods of follow up was similar. The thickest fibrous capsule was observed with silicone implants (average, 28.38 +/- 11.17 microm). This area was thinner with methacrylic hydrogel implants (average, 14.90 +/- 5.57 microm) and was thinnest around sodium hyaluronate implants (average, 7.21 +/- 2.33 microm). For each type of implant, the wall on the conjunctival side of the fibrous capsule was significantly thicker than the wall on the choiroidal side. The space between the implant, scleral flap, and bed was filled soon after surgery with connective tissue rich in vessels. In our study, cross-linked sodium hyaluronate had the highest intrascleral biocompatibility. Although the inflammatory responses of the sclera to methacrylic hydrogel and silicone rubber were similar in nature, a thicker fibrous capsule was generated around silicone implants.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17022058</PMID><DateCompleted><Year>2007</Year><Month>06</Month><Day>11</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>30</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1552-4973</ISSN><JournalIssue CitedMedium="Print"><Volume>81</Volume><Issue>2</Issue><PubDate><Year>2007</Year><Month>May</Month></PubDate></JournalIssue><Title>Journal of biomedical materials research. Part B, Applied biomaterials</Title></Journal><ArticleTitle>Histological biocompatibility of new, non-absorbable glaucoma deep sclerectomy implant.</ArticleTitle><Pagination><MedlinePgn>403-9</MedlinePgn></Pagination><Abstract><AbstractText>We performed this study to compare the intrascleral biocompatibility of three materials: non-absorbable hydrogel contact lens polymer, non-absorbable silicone rubber, and absorbable cross-linked sodium hyaluronate. Intrascleral implantation of three different materials was performed in 13 healthy, pigmented rabbits. Implants of methacrylic hydrogel, silicone rubber, and cross-linked sodium hyaluronate were implanted in 10, 8, and 8 eyes, respectively. The animals were euthanized at 7, 30, 180, and 360 days post implantation. The eyes were enucleated and immediately fixed in 10% buffered formalin. Semithin sections were cut and stained with hematoxylin-eosin. Light microscope analysis of the specimens was performed. The least severe inflammatory reaction was observed with cross-linked sodium hyaluronate implants. The number of inflammatory cells in proximity to methacrylic hydrogel and silicone implants at all periods of follow up was similar. The thickest fibrous capsule was observed with silicone implants (average, 28.38 +/- 11.17 microm). This area was thinner with methacrylic hydrogel implants (average, 14.90 +/- 5.57 microm) and was thinnest around sodium hyaluronate implants (average, 7.21 +/- 2.33 microm). For each type of implant, the wall on the conjunctival side of the fibrous capsule was significantly thicker than the wall on the choiroidal side. The space between the implant, scleral flap, and bed was filled soon after surgery with connective tissue rich in vessels. In our study, cross-linked sodium hyaluronate had the highest intrascleral biocompatibility. Although the inflammatory responses of the sclera to methacrylic hydrogel and silicone rubber were similar in nature, a thicker fibrous capsule was generated around silicone implants.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kałuzny</LastName><ForeName>Jakub J</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland. kubeye@poczta.onet.pl</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jóźwicki</LastName><ForeName>Wojciech</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Wiśniewska</LastName><ForeName>Halina</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Biomed Mater Res B Appl Biomater</MedlineTA><NlmUniqueID>101234238</NlmUniqueID><ISSNLinking>1552-4973</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001672">Biocompatible Materials</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003432">Cross-Linking Reagents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020100">Hydrogels</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011109">Polymethacrylic Acids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012826">Silicone Elastomers</NameOfSubstance></Chemical><Chemical><RegistryNumber>9004-61-9</RegistryNumber><NameOfSubstance UI="D006820">Hyaluronic 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effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020100" MajorTopicYN="N">Hydrogels</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008422" MajorTopicYN="N">Materials Testing</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011109" MajorTopicYN="N">Polymethacrylic Acids</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011817" MajorTopicYN="N">Rabbits</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012590" MajorTopicYN="N">Sclera</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012599" MajorTopicYN="N">Sclerostomy</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012826" MajorTopicYN="N">Silicone Elastomers</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>10</Month><Day>6</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>6</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>10</Month><Day>6</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17022058</ArticleId><ArticleId IdType="doi">10.1002/jbm.b.30677</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Pologne</li></country></list><tree><noCountry><name sortKey="J Wicki, Wojciech" sort="J Wicki, Wojciech" uniqKey="J Wicki W" first="Wojciech" last="J Wicki">Wojciech J Wicki</name><name sortKey="Wi Niewska, Halina" sort="Wi Niewska, Halina" uniqKey="Wi Niewska H" first="Halina" last="Wi Niewska">Halina Wi Niewska</name></noCountry><country name="Pologne"><noRegion><name sortKey="Kaluzny, Jakub J" sort="Kaluzny, Jakub J" uniqKey="Kaluzny J" first="Jakub J" last="Kałuzny">Jakub J. 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